Document 0134
 DOCN  M9470134
 TI    Selenium in the maintenance and therapy of HIV-infected patients.
 DT    9409
 AU    Schrauzer GN; Sacher J; University of California, San Diego, Department
       of Chemistry and; Biochemistry, La Jolla 92093.
 SO    Chem Biol Interact. 1994 Jun;91(2-3):199-205. Unique Identifier :
       AIDSLINE MED/94251846
 AB    Due to its antiviral effects and its importance for all immunological
       functions, the administration of selenium is suggested as a supportive
       measure in early as well as in advanced stages of HIV-induced disease.
       Initial observations on the effects of selenium supplementation in
       HIV-infected patients indicate that selenium causes symptomatic
       improvements and possibly slows the course of the disease. As selenium
       inhibits reverse transcriptase activity in RNA-virus-infected animals,
       supplemental selenium could also prevent the replication of HIV and
       retard the development of AIDS in newly HIV-infected subjects. An
       adequate supply of selenium and of antioxidant vitamins is also proposed
       as a measure to reduce the probability of the placental transmission of
       HIV in pregnancy.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY
       Antioxidants/THERAPEUTIC USE  AIDS-Related Complex/DRUG THERAPY  Female
       Human  HIV/*DRUG EFFECTS  HIV Infections/*DRUG
       THERAPY/IMMUNOLOGY/MICROBIOLOGY  Male  Pregnancy  Pregnancy
       Complications, Infectious/DRUG THERAPY  Reverse
       Transcriptase/ANTAGONISTS & INHIB  Selenium/PHARMACOLOGY/*THERAPEUTIC
       USE  Vitamins/THERAPEUTIC USE  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).